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Immunetics introduces a new B. burgdorferi (Lyme)
ELISA kit* based on the C6 peptide of the VlsE protein, offering
a quantum leap forward in accuracy.
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Highlights |
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· Accurate:
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Near Western Blot accuracy in an ELISA · Sensitive ▪ More sensitive in detection of antibodies in early and late Lyme disease than competing kits · Specific
▪ Eliminates
vast majority of other ELISA’s false positives at the
screening step · Broadly applicable ▪ Detects infection with all strains of Borrelia which cause Lyme disease, including European strains B. garinii and B. afzelii · Convenient
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1 hour turnaround time · Cost-effective ▪ Greatly reduces the number of samples sent for expensive confirmatory testing |
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Principle |
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This ELISA is based on the C6 peptide antigen*, a 26 amino acid sequence of the surface protein VlsE. This peptide has been shown to represent the immunodominant portion of VlsE, containing substantially all of the antigenic reactivity of the whole protein. Recent studies have shown that the C6 peptide is a sensitive and specific marker for antibody to B. burgdorferi sensu lato and for the serodiagnosis of Lyme disease.
As the C6 antigen
represents a defined sequence within the protein, cross-reactivity with
antigens found in other organisms is greatly reduced. *U.S. and foreign patents pending |
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Methodology
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C6 ELISA
results match Western Blot results: C6 Pos/Eqv 95% 1.7%Neg 1.1% 2.2%
n = 180 |
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Components |
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Kit information: * For in vitro diagnostic use |
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Immunetics, Inc. © Copyright 2001 Immunetics, Inc. All Rights Reserved. |