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C6 B. burgdorferi (Lyme) ELISA Kit - A new standard in accuracy

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The C6 Kit

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Immunetics introduces a new B. burgdorferi (Lyme) ELISA kit* based on the C6 peptide of the VlsE protein, offering a quantum leap forward in accuracy. 

For In Vitro Diagnostic Use


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Highlights pix.GIF (45 bytes)

·           Accurate:

        Near Western Blot accuracy in an ELISA
      

·        Sensitive

        More sensitive in detection of antibodies in early and      late Lyme disease than competing kits

·         Specific

         ▪  Eliminates vast majority of other ELISA’s false    positives at the screening step
   ▪  Significantly higher specificity than competing ELISAs

·         Broadly applicable

        ▪  Detects infection with all strains of Borrelia which cause Lyme disease, including European strains B. garinii and B. afzelii

·         Convenient

           1 hour turnaround time
        
  Breakaway strips for any number of samples
        
  Ready-to-use reagents, controls included

·         Cost-effective

          ▪  Greatly reduces the number of samples sent for      expensive confirmatory testing

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Principle pix.GIF (45 bytes)

This ELISA is based on the C6 peptide antigen*, a 26 amino acid sequence of the surface protein VlsE.  This peptide has been shown to represent the immunodominant portion of VlsE, containing substantially all of the antigenic reactivity of the whole protein.  Recent studies have shown that the C6 peptide is a sensitive and specific marker for antibody to B. burgdorferi sensu lato and for the serodiagnosis of Lyme disease.

As the C6 antigen represents a defined sequence within the protein, cross-reactivity with antigens found in other organisms is greatly reduced. 
 

*U.S. and foreign patents pending

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Methodology

 

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C6 ELISA results match Western Blot results:

                                    Western Blot                                          Pos       Neg

 C6        Pos/Eqv             95%       1.7%
             Neg                   1.1%      2.2%

n = 180
Concordance with WB = 97.2%
      

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Components pix.GIF (45 bytes)

Kit information:

  • Cat # DK-E352-096
     
  • Contains a coated microwell plate with 96 breakaway wells, controls and all reagents necessary to perform the assay.

        *  For in vitro diagnostic use

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Immunetics, Inc.
27 Drydock Ave., 6th Floor, Boston MA USA
Tel: 617.896-9100     Toll-Free: 800.227.4765
Fax: 617.896.9110     email: info@immunetics.com

© Copyright 2001 Immunetics, Inc. All Rights Reserved.
Miniblot, Miniblotter and Immunetics are registered trademarks, and C6 Lyme ELISA, MiniSlot and QualiCode are trademarks of Immunetics, Inc.